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HU58™ is a high potency dose of spore based Bacillus subtilis HU58 formulated to enhance the efficacy of MegaSporeBiotic™.  Shelf stable.

HU58 is recommended with:

  • Hepatic encephalopathy
  • Inflammatory bowel diseases like ulcerative colitis and Crohn’s disease
  • C. diff infections
  • Gut infections like SIBO, Candida, parasites, and more
  • Frequent travel

The main benefits of taking additional Bacillus subtilis include:

  • 100% survivability in the digestive tract
  • Competitive exclusion of other bacteria, fungi, and parasites
  • 20% reduction in ammonia and hydrogen gas
  • 40% increase in short-chain fatty acid (SCFA) production
  • Decreased gut inflammation
  • Improved digestion
  • Immune modulation
  • Active gut reconditioning in antibiotic-rich environments


Long before the days of antibiotics, Bacillus subtilis was used as a powerful probiotic treatment for many digestive symptoms, including traveler’s diarrhea and acute diarrhea in children. By the mid-1900’s, cheap antibiotics began to replace this probiotic in the US markets in the interest of cutting healthcare costs. However, the rest of the world continues to use Bacillus subtilis for a variety of GI symptoms.



Bacillus subtilis is a very robust probiotic that forms an outer protective shell, known as an endospore. This impenetrable coating protects the bacterium from harsh environments, including heat, acid, pressure, light, and lack of oxygen. The rugged nature of Bacillus subtilis makes it the perfect probiotic to survive manufacturing, packaging, shipping, and ultimately digestion. In fact, this species is so resilient that researchers at California Polytechnic State University reported reviving Bacillus spores from the gut of a 25-million-year-old bee that was fossilized in amber.


Competitive Exclusion

Studies have demonstrated that Bacillus spores have the ability to produce their own targeted antimicrobials against harmful organisms in the gut. In this way, the spores are able to recondition the gut and foster a more diverse gut microbiome. For this reason, HU58 is especially effective as adjunct treatment for gut infections like SIBO, Candida, C. diff, parasites, and more. HU58 is even effective in the presence of broad-spectrum antibiotics, like Rifaximin, so it is safe to use in conjunction with other treatment methods.


Improved Digestion

You may have heard that “you are what you eat,” but a more accurate phrase would be that “you are what you digest and absorb.” Digestion begins in the mouth with digestive enzymes present in saliva. Your body then relies on you to chew your food into small pieces before sending it through your stomach acid for further breakdown. Once your food passes through the stomach, the final step of digestion relies almost entirely upon the digestive enzymes from your pancreas. Bacillus subtilis helps to improve digestion by increasing the production of digestive enzymes in the gut, including amylase, protease, lipase, and more.


Hepatic Encephalopathy

In a phase 2 double-blind, placebo-controlled study of 40 subjects with hepatic encephalopathy, researchers found that subjects with base ammonia levels greater than 60 µmol/L saw a statistically significant reduction in ammonia levels in just 4 weeks of treatment with HU58. More research is necessary to better understand the correlation, but HU58 may be a valuable adjunct therapy for hepatic encephalopathy patients with ammonia levels above 60 µmol/L, even with antibiotic and lactulose treatment.


Dosing Instructions:   1-2 capsules daily as needed.


Safety Information

If pregnant or nursing, consult your health-care practitioner before using this product. Do not use in children without a doctors permission.

Legal Disclaimer

*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Please contact your healthcare professional immediately if you experience any unwanted side effects. The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking this or any other product.

Additional information

Weight .06 kg
Brand Name

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